郭鹏琦
副教授、硕士研究生导师
电话：15129012029 邮箱：guopengqi@hotmail.com
教育背景
西北大学 (211院校) 2008-2012 化工学院制药工程系学士学位
西安交通大学(985,211院校) 2012-2018 药学院药物分析学系博士学位
工作经历
澳门大学 2017.4-2018.4 中华医药研究院/中药质量研究国家重点实验室 Research Assistant
西北大学 (211院校) 2018.9-今 化工学院制药工程系副教授
科研经历
主要研究方向包括药物新剂型研究；新型功能材料开发；药物分离与分析技术、快速检测技术等。
主持陕西省自然科学基金项目“‘宽覆盖’中药潜在肝毒性皂苷类组分分析模型的建立及评价”、“低壁垒、双靶向治疗药物在线监测新方法的建立及理论基础研究”中国博士后科学基金面上项目“双靶标中药活性成分抗蒽环心脏毒性药物筛选模型的建立及其理论基础研究”等研究项目。参与国家自然科学基金项目“青霉素类抗生素中高分子杂质识别方法的建立与应用”(81173024)；“天然药物中目标物快速‘识别鉴定’二维色谱仪研制”(81227802)；“基于OATs转运蛋白和DNA嘌呤加合物的中药肾毒性分析模型的建立与评价”(81573391)；“基于MIPs-DNA适配体识别技术的甾体激素生产过程废液在线分析方法的建立与评价（81773689）”；“黄连通过肠道菌调节肠外排蛋白P-gp修复UC肠屏障损伤的作用机制研究“（81603370）；陕西省中医药管理局项目“中药制剂中非法添加物的快速分析方法的建立与应用”(15ZY027)等科研项目，澳门科学技术发展基金项目“一种基于纳米酶-分子印迹-量子探针技术的有机磷农药残留快速灵敏检测体系的构建”。同时参与“绝缘油中金属钝化剂质量研究”、”奥拉西坦质量研究“、”维生素B2仿制药一致性评价“等企业委托课题的研究工作。
发表论文
[1] Pengqi Guo, Zhimin Luo, Xinya Xu, Yulan Zhou, Bilin Zhang, Ruimiao Chang, Wei Du, Chun Chang and Qiang Fu, Development of molecular imprinted column-on line-two dimensional liquid chromatography for selective determination of clenbuterol residues in biological samples. Food Chemistry, 2017, 217: 628–636.
[2] Pengqi Guo, Xinya Xu, Liang Xian, Yanhui Ge, Zhimin Luo, Wei Du, Wanghui Jing, Aiguo Zeng, Chun Chang and Qiang Fu, Development of molecularly imprinted column-on line-two dimensional liquid chromatography for rapidly and selectively monitoring estradiol in cosmetics. Talanta, 2016, 161: 830–837.
[3] Pengqi Guo, Xinya Xu, Guoning Chen, Kamran Bashir, Hua Shu, Yanhui Ge, Wanghui Jing,Zhimin Luo, Chun Chang and Qiang Fu, On-Line two dimensional liquid chromatography based on skeletontype molecularly imprinted column for selective determination ofsulfonylurea additive in Chinese patent medicines or functional foods. Journal of Pharmaceutical and Biomedical Analysis, 2017, 146: 292–301.
[4] Pengqi Guo,Wu Yang, Hao Hu, Yitao Wang, Peng Li. Rapid detection of aflatoxin B1 by dummy template molecularly imprinted polymer capped CdTe quantum dots. Analytical and Bioanalytical Chemistry, 2019, DOI:10.1007/s00216-019-01708-2.
[5] Pengqi Guo, Guoning Chen, Hua Shu, Peng Li, Pei Yu, Chun Chang, Yitao Wang, Qiang Fu,Monodisperse molecularly imprinted microsphere cartridges coupled with HPLC for selective analysis of dexamethasone and hydrocortisone in cosmetics by using matrix solid-phase dispersion. Analytical Methods, 2019, 11: 3687-3696.
[6] Pengqi Guo, Fanru Zhong, Yongze Zhao, Xinya Xu, Weiming Xue, Yichen Wang, Xiaoping Song, Weili Tang, Daidi Fan. Thermosensitive molecularly imprinted polymer coupled with HPLC for selective enrichment and determination of matrine in traditional Chinese medicine. Journal of Chromatography B, 2022, 1191: 123130.
[7] Xinya Xu, Yundong Xie, Pengqi Guo, Yongheng Shi, Meng Sun, Jing Zhou, Chuan Wang, Chaojun Han, Jiping Liu, Ting Li. Facile synthesis of novel helical imprinted fibers based on zucchini-derived microcoils for efficient recognition of target protein in biological sample. Food Chemistry, 2023, 404: 134645.
[8] Enmin Wang, Huiyun Wen, Pengqi Guo, Yane Luo, Cunjin Wang, Zhi He, Junxue Pan, Xin Chen, Bo Cao, Yaru Wang, Saipeng Huang, Weiming Xue. Fabrication of methacrylated casein/alginate microspheres crosslinked by UV light coupled with Ca2+ chelation for pH‑sensitive drug delivery. Colloid and Polymer Science, 2022, DOI:/10.1007/s00396-021-04917-3.
[9] Xinya Xu, Pengqi Guo, Hua Shu, Kenan Qu, Yanhui Ge, Guoning Chen, Zhimin Luo, Wei Du, Chun Chang, Ruilin Liu, Qiang Fu. Preparation of biocompatible molecularly imprinted film on biowastederived magnetic pomegranate rind carbon for protein recognition in biological sample. Materials Science & Engineering C, 2020, 115: 111063.
[10] Kamran Bashir, Pengqi Guo, Guoning Chen, Yunzhe Li, Yanhui Ge, Hua Shu, Qiang Fu. Synthesis, characterization, and application of griseofulvin surface molecularly imprinted polymers as the selective solid phase extraction sorbent in rat plasma samples. Arabian Journal of Chemistry, 2020, 13: 4082-4091.
[11] Guoning Chen, Pengqi Guo, Yan Wang, Lu Wang, Hua Shu, Yunzhe Li, Wanghui Jing, Chun Chang, Qiang Fu. Preparation of molecularly imprinted polymers and application in a biomimetic biotin-avidin-ELISA for the detection of bovine serum albumin. Talanta, 2019, 198:55-62.
[12] Wei Du, Bilin Zhang, Pengqi Guo, Guoning Chen, Chun Chang, Qiang Fu. Facile preparation of magnetic molecularly imprinted polymers for the selective extraction and determination of dexamethasone in skincare cosmetics using HPLC. Journal of Separation Science, 2018, 41:2441–2452.
[13] Penglei Zheng, Bilin Zhang, Zhimin Luo, Wei Du, Pengqi Guo, Yulan Zhou, Ruimiao Chang, Chun Chang and Qiang Fu, Facile preparation of polydopamine-coated imprinted polymers on the surface of SiO2 for estrone capture in milk samples. Journal of Separation Science,2018, 41:2585-2594.
[14] Xinya Xu, Ruilin Liu, Pengqi Guo, Zhimin Luo, Xiang Cai, Hua Shu, Yanhui Ge, Chun Chang, Qiang Fu. Fabrication of a novel magnetic mesoporous molecularly imprinted polymer based on pericarpium granati-derived carrier for selective absorption of bromelain. Food Chemistry, 2018, 256: 91-97.
[15] Hua Shu, Yanhui Ge, Xinya Xu, Pengqi Guo, Zhimin Luo, Wei Du, Chun Chang, Ruilin Liu, Qiang Fu. Hybrid-type carbon microcoil-chitosan composite for selectiveextraction of aristolochic acid I from Aristolochiaceae medicinal plants. Journal of Chromatography A, 2018, 1561: 13-19.
[16] Xinya Xu, Pengqi Guo, Zhimin Luo, Yanhui Ge, Yulan Zhou, Ruimiao Chang, Wei Du, Chun Chang and Qiang Fu, Preparation and characterization of surface molecularly imprinted films coated on multiwall carbon nanotubes for recognition and separation of lysozyme with high binding capacity and selectivity. RSC Advances, 2017, 7: 18765-18774.
[17] Yanhui Ge, Pengqi Guo, Xinya Xu, Guoning Chen, Xuemei Zhang, Hua Shu, Bilin Zhang, Zhimin Luo, Chun Chang and Qiang Fu. Selective analysis of aristolochic acid I in herbal medicines by dummy molecularly imprinted solid-phase extraction and HPLC. Journal of Separation Science. 2017, 40(13):2791-2799.
[18] Weiwei Wang, Zhimin Luo, Pengqi Guo, Huiyan Zhou, Qiang Fu and Chun Chang, Selective preconcentration of mezlocillin from eggs by molecularly imprinted polymers on silica. Analytical Letters, 2017, 50(8): 1276-1291.
[19] Weili Tang, Wei Du, Pengqi Guo, Ningli Wu, Kangli Du, Changgen Xu, Zhimin Luo, Ruimiao Chang, Aiguo Zeng, Wanghui Jing, Chun Chang, Ji Li and Qiang Fu, Molecularly Imprinted Solid Phase Extraction using bismethacryloyl β-cyclodextrin and Methacrylic Acid as Double Functional Monomers for Selective Analysis of Glycyrrhizic Acid in Aqueous Media. Journal of Chromatographic Science 2016, 54: 1-8.
[20] Zhimin Luo, Hua Shu, Pengqi Guo, Penglei Zheng, Xiaoyan Pan, Wei Du, Ruilin Liu, Aiguo Zeng, Chun Chang and Qiang Fu, Study of the allergenic benzypenicilloyl–HSA and its specific separation from human plasma by a predesigned hybrid imprinted membrane. RSC Advances, 2016, 6: 15549-15557.
[21] Wanghui Jing, Ruilin Liu, Wei Du, Zhimin Luo, Pengqi Guo, Ting Zhang, Aiguo Zeng, Chun Chang and Qiang Fu, Pharmacokinetic and metabolic characteristics of herb-derived khellactone derivatives, a class of anti-HIV and anti-hypertensive: a review. Molecules, DOI: 10.3390/molecules21030314
[22] Kangli Du, Zhimin Luo, Pengqi Guo, Weili Tang, Ningli Wu, Penglei Zheng, Wei Du, Aiguo Zeng, Wanghui Jing, Chun Chang and Qiang Fu, Preparation and evaluation of a molecularly imprinted sol–gel material as the solid-phase extraction adsorbents for the specific recognition of cloxacilloic acid in cloxacillin. Journal of Separation Science, 2016, 39: 483-489.
[23] Zhimin Luo, Wei Du, Pengqi Guo, Penglei Zheng, Ruimiao Chang, Jin Wang, Aiguo Zeng, Chun Chang and Qiang Fu, A porous hybrid imprinted membrane for selectively anchoring target proteins from a complex matrix. RSC Advances, 2015, 5: 72610-72620.
[24] 傅强, 王薇薇, 杜玮, 郭鹏琦, 周会艳, 常春.一种美洛西林钠硅胶表面分子印迹聚合物的制备方法,ZL201310544417.X,2016,3.
[25] 傅强, 徐欣雅,刘瑞林, 郭鹏琦, 周玉兰, 曾爱国,常春.磁性碳材料表面菠萝蛋白酶分子印迹聚合物的制备方法, ZL201611200968.4, 2018,11.
[26] 傅强, 陈国宁, 郭鹏琦, 舒花,王燕，王璐,常春.牛血清白蛋白磁性仿生免疫分析试剂盒及其应用, ZL201811296410.X, 2020,6.
[27] 傅强, 陈国宁, 郭鹏琦, 徐欣雅,罗智敏,杜玮,常春.可在线切换实现多柱串联的固相萃取装置及其萃取方法. ZL201610472024.6, 2018,12.
